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Refrigeration System of a Freeze Dryer
The job of the refrigeration cycle is to remove unwanted heat from one place and discharge it into another. The refrigeration system of a...
Spray drying as alternative to Lyophilization in the Pharmaceutical Industry
Removal of water through drying provides numerous benefits in addition to improved stability, including ease of handling/storage and...
Application of Isolation Technology in COVID-19 Vaccine Production
On April 12, 2020, a new drug declared by Sinopharm, novel coronavirus inactivated vaccine, was granted the clinical trial approval by...
Residual Moisture Content in Lyophilized Drugs
Residual moisture is a critical parameter for stability of the API in lyophilized drug products, and well-known quality attribute (CQA)...
TDLAS Applications during Lyophilization
Absorption spectroscopy using the diode lasers has been employed to measure the temperatures and concentrations for at least 40 years....
KUFill - An Advanced Flexible Injectables System Integrated with Isolator
Aseptic processing line integrated with Isolator is applied to biotech industry, aiming at oncology drugs, novel injections and antibody...
Lyophilization Glass Vials Problems
Glass vials are nowadays one of the most important components in the pharmaceutical industry, protecting delicate active ingredients...
Check list for the Integration of Lyophilization and Aseptic Filling Equipment
Combining lyophilization and aseptic filling processes presents some design challenges, regardless of the integration of one or more...
Vacuum-Foam Drying: The Alternative for Lyophilization of Biologics?
The complexity of biologics drugs in development continues to increase as the capability in discovery and recombinant technology...
The Challenge of Glass Vial Breakage During Lyophilization
Lyo-breakage is generally not a routine occurrence; however, even at a persistent low frequency it can have significant cost and...
Contamination Control Strategy with Tofflon Isolator
On February 20, 2020, a new draft of EU GMP Annex 1 was finally released. Robotic technology, Barrier System, rapid microbial testing and...
Primary Drying: The Longest and Most Critical Step
Although the entire freeze-drying process is an energy intensive, time-consuming, and economically expensive process, the primary drying...
Adoption of Controlled Ice Nucleation Technology
One of the keys to successful lyophilization is the ability to control ice nucleation so that each vial freezes at the same time and...
Unlock the Potential of Your Vial Filling Line
Glass vial failures, specifically breakage, lensing, and cracks, are a source of product loss and process cost in the freezethaw,...
Lyophilization and COVID19
SARS-CoV-2 is a new virus responsible for an outbreak of respiratory illness known as COVID-19, which has spread to several countries...
Breakage during fill-finish pharmaceutical manufacturing
Fill-finish operations are generally the most capital-intensive stage of the drug manufacturing process — heavy asset utilization is...
Lyophilization of Bacteriophages
Developing resistance among bacteria towards all the available antibiotics makes the clinical treatment of infections more serious and...
Temperature measurement in Lyophilization with Tempris sensors
The importance of product temperature during lyophilization of proteins, microorganisms and other active pharmaceutical ingredients is...
Small Batch Size Lyophilization: A current trend in the biopharmaceutical industry
Patient centered manufacturing instead of a bulk approach is trending in the biopharmaceutical industry. Notably in the fields of...
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