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March 24, 2020

One of the keys to successful lyophilization is the ability to control ice nucleation so that each vial freezes at the same time and produces a high-quality product with less variability and greater efficiency.

Although there are several methods to achieve controlled nu...

March 24, 2020

Glass vial failures, specifically breakage, lensing, and cracks, are a source of product loss and process cost in the freezethaw, cryogenic preservation, and lyophilization of pharmaceutical products. Lyophilization is a common method for the preparation of freezedried...

March 2, 2020

SARS-CoV-2 is a new virus responsible for an outbreak of respiratory illness known as COVID-19, which has spread to several countries around the world.

Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major...

February 25, 2020

Fill-finish operations are generally the most capital-intensive stage of the drug manufacturing process — heavy asset utilization is therefore critical to profitability. Product that has reached the fill-finish stage of manufacturing has the greatest value. Process cha...

February 5, 2020

Developing resistance among bacteria towards all the available antibiotics makes the clinical treatment of infections more serious and difficult. Alternative therapy is required to control the dissemination of antibiotic-resistant bacterial infections. Bacteriophage us...

February 2, 2020

The importance of product temperature during lyophilization of proteins, microorganisms and other active pharmaceutical ingredients is not in doubt, as it determines the quality of the product as long as the formulation-specific maximum product temperature is not excee...

January 29, 2020

Patient centered manufacturing instead of a bulk approach is trending in the biopharmaceutical industry. Notably in the fields of oncology, immunology and neurology, biologics are in high demand and their contribution is still growing. To ensure flexibility, time, and...

January 20, 2020

Glass is the gold standard material for parenteral packaging applications given its chemical durability, optical clarity, and thermal and mechanical performance. However, conventional glass packaging is not without limitations. All glass containers possess surface flaw...

December 3, 2019

The conditions under which pharmaceutical products are freeze dried are subject to strict standards. Satisfying these requirements is crucial for pharmaceutical companies for proving that their products have been safely manufactured and are suitable to be used in patie...

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