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Upscaling with Teclen Lyoprotect® containers

The transfer of the recipe from laboratory scale to production scale is one of the biggest obstacles for manufacturers.

Freeze drying is a technology that entails a high energy consumption. A poorly optimized recipe can cause the economic cost of making the lyophilized product to explode, in addition to negatively affecting productivity.

A new interesting way to reduce the risk of product loss is by adapting to Teclen Lyoprotect® containers.

Benefits of Teclen Lyoprotect® containers:

  • Volumes can be seamlessly scaled up. The same parameters determined in process development can be used with the different containers, if same filling height is maintained.

  • Consistent concept: container with membrane cover. The same type of membrane with the same specifications is used for all sizes, so the barrier does not change during the upscaling process. Freeze-drying parameters that have already been identified can be transferred and lead to same drying result.

  • Material used for seamless upscale product line (cups and trays): stainless steel 316L (1.4404), polished

  • Engraved serial number facilitates allocation and documentation.


Start with the small cup for process development and scale up to a larger container during production. In case more material is required you only need to order the next size. Trays are customizable in size and can be adjusted to freeze-dryer shelves individually.

Design Features

  • Bacteria-proof container with vapor permeable membrane

  • 100% visual inspection of membrane and components

  • Components comply with the regulations for materials and articles intended to come into contact with food according to (EC) No 1935/2004 and (EU) No 10/2011

  • Lyoprotect® Membrane: expanded PTFE on polypropylene non-woven backing material

  • Lyoprotect® Membrane does not contain any material of animal origin

Make sure to contact Anja and discover more!

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