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Corning Valor® Vials Demonstrate Superior Performance by Resisting Breakage During Low Temperature P

Glass vial failures, specifically breakage, lensing, and cracks, are a source of product loss and process cost in the freeze-thaw, cryogenic preservation, and lyophilization of pharmaceutical products. Lyophilization is a common method for the preparation of freeze-dried pharmaceutical products, which requires low temperature processing to avoid product damage or decomposition. Because process times are long and lyophilization is regarded as an expensive process, considerable research has focused on improving lyophilization rates to reduce costs. One contributing factor to cost is the failure of glass vials during the lyophilization cycle, which includes freezing, annealing, and drying proce

Splashing? How to avoid it during vials filling process

Nowadays almost 50% of the injectable products that are in clinical trials or are approved for marketing, are freeze dried products. Main reasons are the advantages in stability, easy handling during shipment and an adequate solution to cold chain problems associated with liquid products. During fill-finish manufacturing of freeze dried products, the vials filling process is a critical unit operation. One of the major risks during vials filling is the so called “splashing”. SPLASHING Splashing is a common challenge with high speed vials filling. The cause of the phenomenon is higher solution velocity of the product in the vial, due to high vials fill speed. Splashing is also an undesirable p

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