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Freeze drying Probiotics?

The name probiotic comes from the Greek words pro bios meaning “for life”. Probiotics is known to give beneficial effect on human body such as improving intestinal motility, strengthening immunity, reducing atopic diseases and suppressing noxious germs. In the past, the general way to ingest probiotics were drinking liquids, though there is a limitation in terms of storage time and practical efficacy. Freeze drying technology opened a new way of consuming probiotics with higher efficacy and with long-term storage time by freeze drying, as well as diversify applications for these kind of products - cosmetic is one of them by applying probiotics on various products such as serum or gel masks.

Interview with Richard Denk

Have you ever joined Richard Denk in a PDA Chapter? LyophiliationWorld is glad to propose an interview with the most reputable expert in Containment in the industry. Richard is an expert in consulting and planning of high containment HPAPI, ADC, highly active pharmaceutical products for Aseptic Biotech, OSD and API facilities. He is Chair of ISPE in Containment for ISPE (DACH countries). Responsible for the ISPE Containment Manual, he wrote a GMP Paperback on Containment & Hygieninc Design and he is frequently speaker in international conferences. Where do you think Containment is going? The Biopharmaceutical sector is a fast-growing industry with a lot of new innovative medicines to treat a

The Rising of a player: i-Dositecno

The number of parenteral products entering development and reaching the market has increased significantly during the past decade. By some estimates as many as half of all investigational new drug applications consist of biopharmaceuticals, the vast majority of which are manufactured aseptically. Care has been taken in the design of the aseptic processing facility to ensure that it will comply with all global regulatory requirements. Current regulatory guidelines require clinical product to have the same sterility assurance as commercial product. Therefore, the facility must be designed to provide contamination control superior to that of any staffed cleanroom and to achieve near-zero contam

Heraeus Relies on Teclen® Lyoprotect® for the Process Development and Manufacturing of Toxic Substan

The Heraeus Pharmaceutical Ingredients Business Line Within the globally active Global Business Unit Heraeus Precious Metals, the Business Line (BL) Pharmaceutical Ingredients has specialized in the process development and production of highly potent active pharmaceutical ingredients (hAPIs). This ranges from the synthesis of cytotoxic compounds to registration and market launch. All hAPIs for cancer treatment are fully developed and manufactured at the company’s headquarters in Hanau, Germany. Pharmaceutical Ingredients has been US FDA-approved for more than 25 years and in 2018 once again received an award for the high quality and safety standards applied to the production of their hAPIs.

12 steps of Lyophilization History you should know

The origins of freeze drying can be traced back to the 15th century, where a rudimentary form of freeze drying was used by the Incas. Freeze-drying became recognized as an important technique for the preservation of numerous biologicals after centuries. What is in one picture its evolution? LyophilizationWorld has developed the below timeline to comprehend freeze-drying past and present and be part of its future. #Freezedryer #Lyophilizationprocess

The 3 Challenges of integrating Filling line and Freeze Dryer

As the pharma industry evolved the need of automated and integrated lines (filling – freeze-dryer) grew worldwide. In the recent years close to 80% of the pharma freeze-dryers are connected through direct conveyor to the automatic loading system and filling line. After different steps (washing, sterilization etc.) a module fits the filled vials with a rubber stopper as a seal. The stopper is pushed in fully for liquid products but only part of the way for freeze-drying products: a sensor system will check that the stopper is present and that it is inserted to the correct depth. Incorrectly sealed vials will be rejected. Depending on the format chosen, the vials are either fed into the loadin

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