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Miscomprehension about rubber stoppers in Freeze Drying

Lyophilization or Freeze-Drying is broadly used for pharmaceuticals to preserve parenteral drugs properties that are unstable in liquid formulation. Lyophilized drugs have many advantages like prolonged shelf life, easy reconstitution and good stability. Therefore, the container closure integrity (CCI) is crucial for maintaining the stability and sterility of the drug throughout its shelf life. It is a frequent question: what rubber stoppers should be employed for a specific product? Choose the right stopper at the beginning of the product development can save lots of time and money down to the production line. Let’s analyze 3 specific areas where the selection of the right stopper is essen

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